SPIM 2026

Skin Physiology International Meeting

Conceive and show new research ways
in the dermocosmetology field

November 19th & 20th, 2026, Vichy FRANCE

PLANNING AND TOPICS

SPIM 2026 - 10thedition

LONGEVITY & HEALTHY SKIN

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Dr Sibylle JAGER, Scientific Leader, L'OREAL

Longevity - is much within us still a worm ? (Nietzche) View more

Although Longevity is a direct consequence of physiological aging, the underlying molecular mechanisms linking aging to longevity are still not fully understood. Numerous studies in model organisms such as C. elegans identified key genetic déterminants of longevity and aging. It is paramount to investigate if and how these pathways can be translated to human skin aging.
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Dr Maria CAVINATO, Institute for Biomedical Aging Research, University of Innsbruck

Cellular Senescence in Skin Aging and Disease: Emerging Mechanisms and Translational Opportunities View more

Cellular senescence has emerged as a central biological process linking skin aging to the onset and progression of chronic skin disorders. While senescence initially serves as a protective response to cellular stress and damage, the long-term persistence of senescent cells contributes to tissue dysfunction through altered metabolism, impaired mitochondrial quality control, and the secretion of pro-inflammatory and matrix-remodeling factors. In the skin, these mechanisms influence not only chronological and environmental aging but also disease susceptibility and progression.

This lecture will provide an overview of the role of cellular senescence in skin aging and selected dermatological conditions, including cutaneous squamous cell carcinoma, atopic dermatitis, and Hailey–Hailey disease. Particular emphasis will be placed on molecular pathways that regulate senescence-associated phenotypes, including mitochondrial dysfunction, altered proteostasis, and intercellular communication mediated by secreted factors and extracellular vesicles. Recent findings from our work highlight how senescent cell heterogeneity and tissue context shape disease-relevant microenvironments that promote inflammation, impaired regeneration, and tumor-permissive niches.

In addition, emerging therapeutic strategies targeting senescent cells will be discussed, including the development of senolytic and senomorphic compounds designed to selectively eliminate or modulate senescent populations. Finally, the presentation will address ongoing efforts to establish non-invasive methodologies for the detection of senescent cells in human skin, integrating spectroscopic and imaging-based approaches to enable translational applications in diagnosis, monitoring, and personalized intervention. Together, these advances position senescence biology as a promising framework for understanding skin physiology and for developing next-generation therapeutic and diagnostic strategies.
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Prof. Carmit LEVY, School of Medicine, 1026, Tel-Aviv University

Physiological benefit of UV exposure other than vitamin D production

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Dr Anita KRISKO, Aion Research, Goettingen, Germany

Proteostasis, respiration and metabolism: a ménage-a-trois of cellular longevity View more

In cells living under optimal conditions, as well as during stress and aging, protein folding defects are usually prevented by the action of chaperones.

Here, we will discuss a new perspective in which cellular proteostasis, including chaperone activity and protein aggregation, is implicated in basic cellular functioning via its previously unknown crosstalk with metabolism and mitochondrial function. We propose that protein maintenance machineries are not only managers of client misfolded proteins, but also act as key determinants of cellular metabolic activity, thereby representing the main axis of cellular quality control and a central homeostatic mechanism relevant to cellular health and longevity.

These findings populate an important niche in cell biology as well as longevity and diseases, promising the possibility of replacing the need for interventions in the chaperone expression levels by treatment with a single or a group of metabolites. Understanding this crosstalk will enable novel insights into basic cellular functioning, and may shed new light on the process of aging, and neurodegenerative diseases.
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Dr Isabelle ADER, INSERM Researcher, RESTORE Laboratory, INSERM 1301, IHU HealthAge, University of Toulouse

Aging: skin cells as sentinels of healthy ageing

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MICROBIOTA & EPITHELIAL BARRIER

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Dr Ellen Van Den BOGAARD, Radboud University

Various roles of AHR in epidermal function

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Prof. Julia OH, The Jackson Laboratory, US

The human skin microbiome: microbial modulation of skin homeostasis View more

The human skin harbors an abundant microbial ecosystem with bidirectional metabolic exchanges supporting symbiotic and commensal functions. Metagenomic analyses of the diverse skin sites in healthy humans demonstrate that contrasting forces of the skin’s biogeography and individual characteristics shape the skin microbiome and the dynamics of its bacteria, fungi, and viruses. However, we have shown that shifts in the ecological properties of the skin microbiome are significantly associated with aging, skin disease, disease severity, and monogenic skin and immune disorders. We have used a variety of computational and functional approaches, including metagenomics, CRISPRi screening, organoid platforms, transcriptomic and spatial transcriptomics, and other technologies to probe genetic and functional diversity of the skin microbiome.
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Prof. Joël DORÉ, Paris-Saclay University

Human-microbes symbiosis: A target for innovations in prevention and therapies

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Dr Cédric DELEVOYE, Research Director, INSERM U1151/CNRS 8253

Genome photoprotection: connecting intracellular mechanics to pigment organelles positioning

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Pr Marc G.J. FEUILLOLEY, Emeritus Professor, University of Rouen Normandy

Endocrine Microbiology, from gut to skin

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SPIM-SFD Session

Nov. 20th, 2026

14.15 – 16.15

Prof. Saskia ORO, Paris, President of the SFD

Introduction

Prof. Nicolas DUPIN, Paris-Cochin/Port-Royal

Cutibacterium acnes – Pathogenic potential and therapeutic perspectives

Dr Julien SCANZY, Prof. Anthony BUISSON, Clermont-Ferrand

Gut microbiota: Understanding its implications in applied research

Prof. Emilie SBIDIAN, Creteil,

Impact of psoriasis biotherapies on the gut microbiota

Dr Claire HOTZ, Rodez,

Microbiota Modulation in Hidradenitis Suppurativa: From Mechanisms to Therapeutic Opportunities

Moderated by Prof. Marie BEYLOT-BARRY, Bordeaux, Prof. Olivier CHOSIDOW, Paris-Saclay

Q&A Round Table

Marie BEYLOT-BARRY

Conclusion

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The Greentech awards

State of the art in skin physiology

In its will to promote knowledge on skin physiology, and to encourage younger generation of scientists to search further, the Fondation d’Entreprise GREENTECH, organizer of the SPIM – will grant an award to 2 participants in the following categories.

Junior Scientist Award: €10,000

6 junior scientists will be selected and invited by the scientific committee for an oral presentation of their research. Travel and accommodation will be supported by the Committee.

For paper submission guidelines, click here

Best Poster Award: €3,000

All participants, whether they are junior researchers or not, have the opportunity to present a poster related to research on skin physiology. The winning poster will be selected through a vote involving all SPIM participants.

For paper submission guidelines, click here

What is the SPIM?

State of the art in skin physiology

The SPIM is a unique scientific meeting at the crossroads of research excellence and international conviviality. Putting latest research work and discoveries on skin physiology at its center, the event aims at sharing and mixing thoughts, views and investigation methods between various disciplines without dogmatic position.

It involves experts from all specialisations (physiologists, biochemists, dermatologists and pharmacologists) and all countries (USA, Great Britain, Germany, Italy, Japan, France, etc) and encourages cross-collaboration to push further scientific understanding of skin physiology and metabolic interactions, for both healthy and disorder skin states.

Each SPIM has been and is designed in collaboration with our scientific committee gathering renowned Scientists and Physicians with large experience in the area of skin physiology, dermatology and cosmetology.