Spim 2020

Skin physiology international meeting


University Registered Students
Karolinska Institute, Stockholm, Sweden “Epidermal stem cells at the point of no return” Karl ANNUSVER
Medical University of Vienna, CEMM, Austria “Impact of the microbiome in graft-versus-host disease development after allogeneic hematopoietic stem cell transplantation” Nadine BAYER
UMR144, Institut Curie, Paris, France “Characterization and modulation of the pigment reservoir in keratinocyte” Silvia BENITO-MARTINEZ
LBTI, CNRS UMR 5305, Lyon, France “Decoding the microRNA message transmitted in human epidermis during chronological aging” Dr Alejandro GONZALES TORRES
Karolinska Institute, Stockholm, Sweden “Decoding embryonic skin at the time of hair follicle induction” Tina JACOB
CEA/ University Paris Saclay, France “Immune profile of human cutaneous keratinocyte precursors” Guillaume MESTRALLET
IGFL, ENS Lyon, France “The antioxidant transcription factor Nrf2 is a key player in dermal homeostasis by regulating extracellular matrix genes in human skin fibroblasts” Melanie SALAMITO
University of Toulouse (UDEAR), France “Nociceptive sensory neurons, key regulators of allergic skin inflammation” Nadine SERHAN
INSERM U1065, C3M, Nice, France “Epigenetic mechanisms of SIRT6 in melanoma resistance and genome integrity” Dr Thomas STRUB


UMR 5305, CNRS/UCBL1, Lyon, France “Cutaneous neurovascular function in wound healing” Dr Bérengère FROMY
Hair Science Institute Maastricht, The Netherlands “Microcirculation disturbances due to high venous pressure; The relation with non-healing leg ulcers” Prof. Martino NEUMANN
St John’s Institute of Dermatology, London, UK “Molecular therapies for basement membrane zone disorders” Dr Su LWIN
Medical University of Vienna, Austria “Cell type-specific control of skin ageing by autophagy” Prof. Leopold ECKHART
Medical School, University of Crete, Heraklion, Greece “Autophagic pathways in physiology and pathology during ageing” Prof. Nektarios TAVERNARAKIS
Karolinska Institute, Sweden “Decoding the molecular anatomy of the skin” Dr Maria KASPER
INSERM-University of Toulouse, France “Deimination in epidermal barrier and hair formation” Dr Michel SIMON
University Hospital Salzburg, Austria “miRNA at the single cell level in squamous cell carcinomas of dystrophic bullosa” Prof. Johann BAUER
Radboud University, The Netherlands “Skin microbiome, AhR and pollution” Dr Ellen VAN DEN BOGAARD
Epidermal Biology Laboratory, Innsbruck, Austria “Metabolism of xenobiotics in the epidermis: implications in skin diseases” Dr Sandrine DUBRAC
Namur University, ASBL, Belgium “Regulation of fungal infection of the epidermis” Prof. Yves POUMAY

Lauréats 2020


Greentech Awards

The Scientific Committee selected the “Best Junior Scientist 2020“ among the 9 young researchers (PhD or post-PhD) nominated and invited to present their results to Scientists and Industrials coming from the Dermatology and Cosmetic Worlds.

The Scientific Committee awarded a young and expert scientist for her outstanding work, Ms Silvia BENITO-MARTINEZ.

She received the grant of €15,000.

Her scientific project was :
Characterization and modulation of the pigment reservoir in keratinocyte

The aim of the project was to establish and to validate the first in vitro system that allowed studying the pigmentation of keratinocytes and which behaved physiologically recapitulating the features reported in situ in human skin. The system was made of isolated melanocores and normal human keratinocytes allowing to quantitatively track the intracellular location and integrity of individual melanocores.

The new model will be exploited using biochemistry, electron and optical microscopies to define the cellular and molecular bases and associated pigmentary processes taking place in the keratinocytes. It will allow to bring new crucial knowledge in the field of cell biology, pigmentation and skin photo-protection allowing to open new avenues in order to design strategies modulating pigmentation in health and diseases.


Concerning the « Best SPIM Poster 2020 », Nadine SERHAN’s poster was selected by all participants and received the grant of €4,000.

Her topic was :
Nociceptive sensory neurons, key regulators of allergic skin inflammation

The study offers direct evidence of the functional interplay between the nervous and immune systems in the context of allergic skin inflammation. Upon exposure to prevalent house dust mites, sensory neurons (also called nociceptors) are activated to release substance P that, in turn, triggers mast cell degranulation, via the activation of their newly-described receptor for cationic molecules, Mas Related G protein-coupled Receptor B2 (MRGPRB2); what results in the development of atopic dermatitis-like allergic skin inflammation. Targeting these nociceptor-mast cell interactions might therefore represent a promising therapeutic approach for the prevention and/or treatment of atopic dermatitis.