Spim 2022

Skin physiology international meeting


University Registered Students
Institute for Stem Cell Science and Regenerative Medicine Bangalore, India “Novel therapy for non-healing diabetic wounds through the understanding of mechanical and epigenetic pathways of wound healing” Tanay BHATT
CNRS LBTI, Lyon, France “The nuclear translocation of the GPRC5A receptor is implicated in human keratinocyte adhesion and migration” Sarah CHANTELOUBE
UMR 5305, University of Lyon, France “Identification of extracellular matrix-derived biomarkers and therapeutic targets in Dystrophic epidermolysis bullosa” Mélissa DUSSOYER
Institute for Stem Cell Science and Regenerative Medicine Bangalore, India “The neuropeptide Substance P modulates fibroblast responses during thecutaneous wound healing program” Dyuti SAHA
University Claude Bernard Lyon 1, France “Role of the epidermal TRPV3 channel in cutaneous thermoregulation during aging” Lisa MARTIN
Institute for Stem Cell Science and Regenerative Medicine Bangalore, India “The Non-immune function of immune cells in skin fat homeostasis” Edries YOUSAF HAJAM
Sorbonne University, Paris “A perfusable vascularized full thickness skin model for topical and systemic applications” Sacha SALAMEH
Medical University of Gdańsk, Poland “Efficacy of Botulinum Toxin in the treatment of patients suffering from Hidradenitis Suppurativa” Milosz LEWANDOWSKI
Toulouse University, France “Cold Atmospheric Plasma Jet Treatment Improves Human Keratinocyte Migration and Wound Closure Capacity without Causing Cellular Oxidative Stress” Aurélie MARCHÈS


INSERM, IRCAN, Nice, France “Premature aging and mechanosensing” Dr Chloé FÉRAL
CBI, CNRS-UMR5088, University Toulouse III Paul Sabatier, France “Architectural role of nuclear envelope on homeostasis of DNA and telomeres” Dr Laure CRABBE
CNRS, LBTI, Lyon, France “Elastic microenvironment of skin cells: drift and repair” Dr Romain DEBRET
Skin Research Institute of Singapore & UK “Keratin Filaments in Skin: Linking Mechanics to Skin Physiology” Prof. Birgit LANE
CECAD Research Center, Cologne, Germany “Insulin/IGF-1 signaling in skin physiology and pathology” Prof. Carien M NIESSEN
RDP Institute at ENS Lyon, INRAE, France “Life, as a suboptimal path” Prof. Olivier HAMANT
IRCAN, Medical school, CRCN-CNRS, Nice, France “Senescence associated Immune Checkpoint: a paradigm shift in Cancer & Aging ?” Dr Julien CHERFILS
Queen Mary University of London, UK “Enhancing antigen-specific immunity in older adults using anti-inflammatory drugs.” Dr Emma CHAMBERS
DBT-InStem, Bangalore, India “Immunosenescence in wound healing” Prof Colin JAMORA
UMRS INSERM U1050 - CNRS 7241, Collège de France, Paris, France “Skin models, recent advances” Dr Stéphane GERMAIN
King's College London, UK “Elucidating neurovascular regulatory mechanisms in the cold vascular response” Prof. Susan BRAIN
INSERM U1312, Bordeaux Institute of Oncology, France “Infantile hemangioma sensitivity to propranolol treatment relies on unique cellular and extracellular features” Dr François MOISAN

Lauréats 2022


Greentech Awards

The Scientific Committee selected the “Best Junior Scientist 2022“ among the 9 young researchers (PhD or post-PhD) nominated and invited to present their results to Scientists and Industrials coming from the Dermatology and Cosmetic Worlds.

The Scientific Committee awarded a young and expert scientist for her outstanding work, Ms Sarah CHANTELOUBE, a PhD student working under the supervision of Dr Romain DEBRET in the Tissue Biology and Therapeutic Engineering Laboratory (LBTI), a mixt research unit of the French National Center for Scientific Research (CNRS) and the University Claude Bernard Lyon 1 (UMR 5305) hosted by the Institute of Biology and Chemistry of Proteins (IBCP) in Lyon.

She received the grant of €15,000.

Her scientific project was:

« Strong overexpression of GPRC5A (G Protein-Coupled Receptor Class C Group 5 Member A) in keratinocytes from the skin wound edges was previously observed in vivo, but also in response to stiffness modulations in vitro, concomitantly to the translocation of its C-terminal region into the nucleolus.

To better understand the role of this receptor in keratinocyte mechano-sensing, GPRC5A knock-down was performed in N/TERT-1 cells using a short-hairpin RNA approach, and a recombinant polypeptide mimicking the C-terminal region of GPRC5A (GPRC5A-Cter) was tested to rescue cell phenotype.

Our results demonstrate a new molecular signalling in keratinocytes implicating the C-terminal region of GPRC5A. Moreover, the use of GPRC5A-Cter polypeptide allows partial rescue and would offer an interesting tool to improve the re-epithelialization step ».

Concerning the « Best SPIM Poster 2022 », Dyuti SAHA’s poster was selected by all participants and received the grant of €4,000.

She is a PhD student working in Dr Colin Jamora’s Laboratory at the Institute for Stem Cell Science and Regenerative Medicine in Bangalore, India.

Her scientific topic was : The neuropeptide Substance P modulates fibroblast responses during the cutaneous wound healing program

This study investigated the role of the neuropeptide Substance P (SP) during the cutaneous wound repair. It was found that SP can modulate the behavior of primary human dermal fibroblasts by promoting a transition from inflammatory to proliferation-associated responses. Fibroblasts were grown on a substrate that recapitulated the mechanical properties of in-vivo tissue, revealing novel functions of SP on dermal fibroblasts including an inhibition of the inflammatory response. Further, SP promoted activities crucial to the proliferation phase such as promoting expression of extracellular matrix components and producing angiogenic signals. Interestingly, the effect of SP was reduced upon ageing of the fibroblasts and SP levels were decreased in skin of patients suffering from inflammatory diseases such as scleroderma and psoriasis. Thus, this work raises the interesting possibility of using SP in therapeutic approaches to treat chronic wounds and diseases with an « inflammation signature ».